18 Celebrities Who Died from Prescription Drugs

Just because they’re legal doesn’t mean that pharmaceutical drugs are any less dangerous than illicit drugs. They are potentially deadly when taken in large doses or when combined with alcohol or other drugs. Sometimes it takes high-profile cases to remind us of the dangers. Here are 18 such cases.

MarilynMonroe.jpgMarilyn Monroe
August 5, 1962
Drugs: Pentobarbital (AKA Nembutal) and chloral hydrate (sleeping pills)

The sex symbol actress was found dead at age 36 in her Los Angeles home early on the morning of August 5. The toxicology report showed high levels of two barbiturates in her blood: Nembutal and chloral hydrate. Monroe’s “acute barbiturate poisoning” was listed as a “probable suicide,” but many people believe that it was an accidental overdose or even a murder.

DorothyDandridge.jpgDorothy Dandridge
September 8, 1965
Drug: Imipramine, AKA Tofranil (antidepressant)

The first African-American to be nominated for an Academy Award for Best Actress, the 42-year-old Dandridge was found dead by her manager from what was diagnosed as “acute drug intoxication.” Her death was ruled to be due to an accidental overdose of Tofranil, an antidepressant that she took for what today might be diagnosed as bipolar disorder. Some people claim that she died from combining the Tofranil with pain medication she was taking for a broken ankle.

JimiHendrix.jpgJimi Hendrix
Date: September 18, 1970
Secobarbital, AKA Seconal (sleeping pill)

The influential American guitarist, 27, was found dead in his girlfriend’s London hotel room, although some claim that he died in the ambulance on the way to the hospital. The cause of death noted on the coroner’s report was “inhalation of vomit” after “barbiturate intoxication (quinalbarbitone)”. Quinalbarbitone is the British term for the sleep aid secobarbital; the pills belonged to Hendrix’s girlfriend. His death is believed to have been accidental, although some have suggested suicide.

BruceLee.jpgBruce Lee
Date: July 20, 1973
Drug: Equagesic (painkiller)

The iconic martial artist died in Hong Kong at the age of 32 from swelling of the brain (“acute cerebral edema”) caused by an allergic reaction to the prescription painkiller equagesic, which contains aspirin and the muscle relaxant meprobamate. The pill was given to him by an actress friend after he complained of a headache.

FreddiePrinze.jpgFreddie Prinze
Date: January 29, 1977
Drug: Methaqualone, AKA Quaaludes (sedative)

The young comedian, only 22 at the time of his death, shot himself in the head in a Los Angeles hotel room. What was initially ruled a suicide was later changed to read an “accidental shooting due to the influence of Quaaludes.”


ElvisPresley.jpgElvis Presley
Date: August 16, 1977
Drugs: As many as 14 different drugs, including codeine (painkiller) and methaqualone, AKA Quaaludes (sedative)

The official cause of death of the King of Rock ‘n Roll, then 42, was cardiac arrhythmia (an irregular heartbeat), but it’s generally believed that prescription drugs contributed to his heart condition. Although initial statements from the medical examiner excluded drugs as a cause of death, further investigations found that the singer had been prescribed between 5,000 and 10,000 pills in the eight-month span before his death. Presley’s doctor, Dr. George C. Nichopoulos, explained the singer’s open attitude toward prescription drugs: “He felt that by getting [pills] from a doctor, he wasn’t the common everyday junkie getting something off the street.”

KeithMoon.jpgKeith Moon
Date: September 7, 1978
Drug: Clomethiazole, AKA Heminevrin (sedative)

The Who drummer died in London at age 32 from an accidental overdose of clomethiazole, a drug that was being used to treat his withdrawal symptoms as he attempted to break his addiction to alcohol. However, the sedative, ironically, is itself highly addictive, and medical examiners found 10 times its recommended daily allowance in his system at death.


Abbie HoffmanAbbie Hoffman
Date: April 12, 1989
Drug: Phenobarbital (anti-seizure sedative)

Renowned ’60s political activist Hoffman, 52, passed away in his Pennsylvania apartment from an overdose of phenobarbital (150 tablets), in what was officially ruled a suicide — possibly related to his bipolar disorder.


SteveClark.jpgSteve Clark
Date: January 8, 1991
Drugs: Unspecified antidepressant and painkiller

At the age of 30, Def Leppard guitarist Clark was found dead by his girlfriend in his London home. The cause of death was respiration failure due to an excessive intake of anti-depressants, painkillers (which had been prescribed for a cracked rib) and alcohol. Valium was also found in his system, but not an a harmful level. It was ruled an accidental overdose.

MargauxHemingway2.jpgMargaux Hemingway
July 1, 1996
Drug: Phenobarbital (anti-seizure sedative)

The 42-year-old model and actress was found in her Santa Monica, California apartment, dead from an overdose of phenobarbital. It was declared that she’d committed suicide, a day before the 35-year anniversary of her grandfather Ernest Hemingway’s own suicide.


RobPilatus.jpgRob Pilatus
Date: April 2, 1998
Drug: Unspecified drug, rumored to be methadone (painkiller, anti-addiction aid)

The 32-year-old Milli Vanilli performer, disgraced when it was revealed that he and his partner never actually sang the vocals on their Grammy-winning debut album, died in a Frankfut, Germany hotel room at the age of 32. Although he had previously attempted suicide, his death was pronounced to be from a heart attack due to an accidental overdose of an unspecified medication (rumored to be methadone, ironically used to treat addiction) and alcohol.

DanaPlato.jpgDana Plato
May 8, 1999
Carisoprodol, AKA Soma (muscle relaxant), and Vicodin (painkiller)

The Diff’rent Strokes actress, 34, died in Oklahoma from what was deemed an accidental overdose of two prescription drugs, a muscle relaxant and a painkiller. She had a long track record of abusing prescription drugs, as witnessed by her 1992 arrest for forging a Valium prescription.

OlDirtyBastard.jpgOl’ Dirty Bastard
Date: November 13, 2004
Drug: Tramadol (painkiller)

The mercurial rapper from the group the Wu-Tang Clan died in New York City just two days before his 36th birthday from what was ruled to be an accidental overdose of a painkiller combined with cocaine.


ChrisPenn.jpgChris Penn
Date: January 24, 2006
Drugs: Promethazine (antihistamine) and codeine (painkiller)

Actor Penn, 40, was found dead in his Santa Monica, California home from cardiomyopathy (heart disease), possibly aggravated by the promethazine and codeine in his system. Obesity and an enlarged heart likely also played a part.


GeraldLevert.jpgGerald Levert
Date: November 10, 2006
Drugs: Six drugs: painkillers Vicodin, Percocet and Dextropropoxyphene (AKA Darvocet), sedative/anxiety medication alprazolam (AKA Xanax) and two non-prescription antihistamines

Popular R&B singer Gerald Levert passed away at the age of 40 in his Ohio home from what was labeled accidental acute intoxication due to a combination of prescription and over-the-counter drugs, including painkillers for shoulder and Achilles tendon injuries and Xanax for anxiety attacks.

AnnaNicoleSmith.jpgAnna Nicole Smith
Date: February 8, 2007
Drugs: Eleven drugs, including chloral hydrate (sleep aid) and several sedatives/muscle relaxants: clonazepam (AKA Klonopin), lorazepam (AKA Ativan), oxazepam (AKA Serax) and diazepam (AKA Valium)

The controversial model was 39 when she was found dead in a Florida hotel. After an autopsy, the cause of death was found to be accidental “acute combined drug intoxication,” athough the chloral hydrate (AKA Noctec) specifically was listed in the coroner’s report as the “toxic/lethal drug.” Just five months prior to her death, Smith’s 20-year-old son Daniel had died from taking a combination of the antidepressants sertraline (AKA Zoloft) and escitalopram (AKA Lexapro), along with methadone (painkiller, anti-addiction aid).

PimpC.jpgPimp C
Date: December 4, 2007
Drugs: Promethazine (antihistamine) and codeine (painkiller)

The Underground Kingz rapper passed away in a Los Angeles hotel from an accidental overdose of a homemade drink, nicknamed “syrup,” that is popular in Southern hip-hop culture. Syrup is typically made of prescription-strength cough syrup (containing promethazine and codeine) mixed with benign ingredients like soda or candy. In Pimp C’s case, his overdose combined with his sleep apnea — a condition that causes brief stoppages in breathing while sleeping — to prevent him from breathing, leading to his death. A long proponent of syrup, Pimp C was featured on the 2000 Three 6 Mafia song “Sippin’ on Some Syrup,” which helped introduce the public to the practice of drinking cough syrup as an alternative to alcohol.

HeathLedger.jpgHeath Ledger
Date: February 6, 2008
Drugs: Six drugs: painkillers oxycodone and hydrocodone, sleep aid temazepam and sedatives diazepam (AKA Valium), alprazolam (AKA Xanax) and doxylamine

The acclaimed Australian actor died unexpectedly at age 28 in his New York City apartment. The medical examiner found that “the manner of death is accident, resulting from the abuse of prescription medications,” given the presence of six prescription medications in Ledger’s body.

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